The first total synthesis of sporiolide A.
نویسندگان
چکیده
The first total synthesis of the natural cytotoxic agent sporiolide A has been accomplished from D-glucal in 16 steps with 6.1% overall yield. Carbohydrates were applied as the chiral templates to manipulate the absolute configuration during the synthesis. Pyridinium chlorochromate (PCC)-promoted transformation of the cyclic enol-ether to lactone, followed by Yamaguchi esterification and intramolecular ring closure metathesis, greatly facilitates synthesis of the target compound.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 71 22 شماره
صفحات -
تاریخ انتشار 2006